Long-term remission of APL with a second allogeneic BMT after CNS relapse following HLA-identical allogeneic BMT
نویسندگان
چکیده
منابع مشابه
Dli after Allogeneic Bmt for Scd
Volume 40, September 2000 TRANSFUSION 1071 Sickle cell disease (SCD) may be associated with considerable morbidity and mortality, particularly as patients reach adulthood.1 Among the various therapeutic options, allogeneic HPC transplantation is the only treatment with proven curative potential.1,2 However, the underlying disease recurs in about 10 percent of patients.2 Donor lymphocyte infusio...
متن کاملDoubling down on PKC benefits allogeneic BMT.
integrin (see figure). The binding of Kindlin to the integrin induces a conformational change in the integrin tail that facilitates the integrin to bind to another protein called Talin. Together, the binding of Kindlin and Talin to an integrin induces changes that allow the integrin to bind to its ligand. Until now, it appeared that the Kindlin-associated diseases—Kindler syndrome and leukocyte...
متن کاملUnexpected late graft failure 9 months after HLA-identical bone marrow transplant (BMT) for chronic myeloid leukemia (CML): treatment with a second BMT.
We describe a patient with CML in 1st chronic phase (CP) who experienced a graft failure 9 months after an HLA genotypically identical sibling BMT. Drug toxicity, viral infections, chronic graft-versus-host-disease (GVHD) or leukemic relapse were excluded. Chimerism study showed 85% of donor marrow cells. She underwent a second BMT, reengrafted but died of grade IV acute GVHD.
متن کاملChronic GvHD decreases antiviral immune responses in allogeneic BMT.
Chronic graft-versus-host disease (cGvHD) is associated with functional immunodeficiency and an increased risk of opportunistic infections in allogeneic bone marrow transplantation (BMT). We used a parent to F1 model of allogeneic BMT to test the hypothesis that cGvHD leads to impaired antigen-specific antiviral immunity and compared BM transplant recipients with cGvHD to control groups of allo...
متن کاملIsolated testicular and bone relapse in children with acute myeloblastic leukemia and chronic graft versus host disease after allogeneic BMT.
Isolated extramedullary relapse after allogeneic bone marrow transplantation (BMT) for acute myeloblastic leukemia (AML) is very unusual, particularly in patients with graft versus host disease (GVHD) known to be associated with decreased incidence of leukemic relapses. However, these rare occasions have been suggested to result from the escape of leukemic cells at the immune-privileged sites. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2003
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1704225